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Table 4 Solid phase spectrophotometric determination of salicylate derivatives in real samples using the standard addition method (n = 3, P = 0.95)

From: Silica-titania xerogel for solid phase spectrophotometric determination of salicylate and its derivatives in biological liquids and pharmaceuticals

Sample

Analyte

Found (independent method)

Found (proposed method)

Deep Heat creama

Methylsalicylate

128 mg/g (DC)

123 ± 8 mg/g

Citramon tabletsb

Acetylsalicylic acid

240 mg/tablet (DC)

220 ± 10 mg/tablet

Acetylsalicylic acid tablets Tatkhim

Acetylsalicylic acid

500 mg/tablet (DC)

500 ± 20 mg/tablet

Acetylsalicylic acid tablets Medisorb

Acetylsalicylic acid

500 mg/tablet (DC)

510 ± 20 mg/tablet

Synthetic serumc, containing 1 mM salicylate

Salicylate

1.03 ± 0.05 mM (TT)

0.97 ± 0.15 mM

Urine sampled

Salicylate

0.42 ± 0.01 mM (TT)

0.46 ± 0.07 mM

  1. DC content declared by manufacturer
  2. TT Trinder salicylate test
  3. aContains additional active substances: menthol 59.1 mg/g, eucalyptus oil 19.7 mg/g, turpentine oil 14.7 mg/g
  4. bContains additional active substances: paracetamol 180 mg/tablet, caffeine 30 mg/tablet
  5. cSynthetic serum composition is taken from [12]
  6. dCollected 1 h after oral administration of 1000 mg of acetylsalicylic acid