Table 1 Coefficients in equation one for in vivo processes at 37 °C [1]
From: Using water–solvent systems to estimate in vivo blood–tissue partition coefficients
Process | c | e | s | a | b | v | i |
|---|---|---|---|---|---|---|---|
Blood–brain | 0.547 | 0.221 | −0.604 | −0.641 | −0.681 | 0.635 | −1.216 |
Blood–muscle | 0.082 | −0.059 | 0.010 | −0.248 | 0.028 | 0.110 | −1.022 |
Blood–liver | 0.292 | 0.000 | −0.296 | −0.334 | 0.181 | 0.337 | −0.597 |
Blood–lung | 0.269 | 0.000 | −0.523 | −0.723 | 0.000 | 0.720 | −0.988 |
Blood–kidney | 0.494 | −0.067 | −0.426 | −0.367 | 0.232 | 0.410 | −0.481 |
Blood–heart | 0.132 | −0.039 | −0.394 | −0.376 | 0.009 | 0.527 | −0.572 |
Blood–fat | 0.077 | 0.249 | −0.215 | −0.902 | −1.523 | 1.234 | −1.013 |
Blood–skin | −0.105 | −0.117 | 0.034 | 0.000 | −0.681 | 0.756 | −0.816 |
Water–skin | 0.523 | 0.101 | −0.076 | −0.022 | −1.951 | 1.652 | 0.000 |
Skin permeation | −5.420 | −0.102 | −0.457 | −0.324 | −2.608 | 2.066 | 0.000 |