Scheme 1From: De-novo design, synthesis and evaluation of novel 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as HIV-1 reverse transcriptase inhibitorsSynthesis of final compounds (5a-o), reagents and conditions: (a) DCM, Et3N, 0 °C-rt, 2 h; (b) ACN, K2CO3, Reflux 3–5 hBack to article page