Synthesis, anticholinesterase and antioxidant potentials of ketoesters derivatives of succinimides: a possible role in the management of Alzheimer’s

Table 5 ABTS free radicals scavenging assay of compounds 1-4

Compounds	Conc. (μg/mL)	Percent inhibition (mean ± SEM)	IC₅₀ (μg/mL)
1	1000	88.51 ± 0.62**	90
	500	77.45 ± 0.54***
	250	65.00 ± 0.57***
2	1000	86.49 ± 0.49***	141
	500	72.45 ± 0.65***
	250	59.66 ± 0.66***
3	1000	80.41 ± 0.73***	73
	500	71.25 ± 0.48***
	250	64.67 ± 0.89***
4	1000	73.59 ± 0.43***	173
	500	67.33 ± 0.77***
	250	54.00 ± 1.15***
Ascorbic	1000	91.62 ± 0.62	<0.1
acid	500	87.23 ± 0.47
	250	84.66 ± 0.88

Data is represented as mean ± SEM, n = 3
Two-way ANOVA followed by Bonferroni test was applied for significant difference between standard drugs and test samples at 95 % confidence interval. Values significantly different as compare to positive control, **P < 0.01 and ***P < 0.001

ISSN: 2661-801X