Table 3 Butyrylcholinesterase inhibition of compounds 1-4
Compounds | Concentration | Percent AChEI | IC50 |
|---|---|---|---|
(μg/mL) | (mean ± SEM) | (μg/mL) | |
1 | 1000 | 90.25 ± 0.02 ns | 42 |
500 | 82.50 ± 0.18 ns | ||
250 | 72.50 ± 0.02 ns | ||
2 | 1000 | 90.00 ± 0.10 ns | <0.1 |
500 | 86.75 ± 0.22 ns | ||
250 | 84.25 ± 0.12 ns | ||
3 | 1000 | 89.25 ± 0.50 ns | 7 |
500 | 89.00 ± 0.30 ns | ||
250 | 78.25 ± 0.04 ns | ||
4 | 1000 | 98.50 ± 0.18 ns | 2 |
500 | 88.50 ± 0.50 ns | ||
250 | 87.50 ± 0.04 ns | ||
Galanthamin | 1000 | 94.50 ± 0.71 | 53 |
e | 500 | 85.47 ± 0.59 | |
250 | 71.72 ± 0.51 |