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Table 2 Acetylcholinesterase inhibition of compounds 1-4

From: Synthesis, anticholinesterase and antioxidant potentials of ketoesters derivatives of succinimides: a possible role in the management of Alzheimer’s

Compounds

Concentration

Percent AChEI

IC50

 

(μg/mL)

(mean ± SEM)

(μg/mL)

1

1000

98.00 ± 0.70ns

<0.1

 

500

94.25 ± 0.05 ns

 
 

250

93.25 ± 0.25 ns

 

2

1000

98.75 ± 0.25 ns

<0.1

 

500

91.75 ± 0.04 ns

 
 

250

91.00 ± 0.52 ns

 

3

1000

98.50 ± 0.09 ns

<0.1

 

500

96.00 ± 0.80 ns

 
 

250

95.25 ± 0.20 ns

 

4

1000

97.25 ± 0.07 ns

<0.1

 

500

96.00 ± 0.55 ns

 
 

250

93.25 ± 0.15 ns

 

Galanthamin

1000

94.22 ± 1.01

<0.1

e

500

92.28 ± 0.43

 
 

250

85.35 ± 0.83

 
  1. Data is represented as mean ± SEM, n = 3
  2. Two-way ANOVA followed by Bonferroni test was applied for significant difference between standard drugs and test samples at 95 % confidence interval. Values significantly not different in comparison to standard drug