Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

Table 6 Fungicidal activity of Mannich bases (6a-r) using Nystatin as standard antifungal reference^a

Compound	*Aspergillus niger*	*Candida albicans*	*Fusarium oxysporium*
6a	+	+	+
6b	+	--	+
6c	--	--	--
6d	+++	+++	+++
6e	++	+++	+
6f	+	++	--
6g	++	++	++
6h	+	+	--
6i	--	++	--
6j	++	-	+
6k	++	+++	++
6l	+++	++++	++++
6m	++	--	--
6n	+	+	++
6o	+++	++	--
6p	++++	+++	+++
6q	+++	++	+++
6r	+	+	+
Nystatin	++++	++++	++++

^a The activities are based on the diameter of zones of inhibition in mm. 50 μL of stock solution was applied in each hole of each paper disk. +: <15 mm; ++: 15–24 mm; +++: 25–34 mm; ++++: 35–44 mm.

ISSN: 2661-801X