Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

Table 3 Evaluation of catalytic activity of DBSNa in the synthesis of (5a)^a

Entry	Amount of DBSNa (mol %)	Time (min)	Yield ^b (%)
1	5	90	68
2	10	70	81
3	15	60	87
4	20	60	94
5	25	60	94

^a The reaction was carried out with 1-thia-4-azaspiro[4.5]decan-3-one (3) (10 mmol), benzaldehydes (4a) (10 mmol) and DBSNa in 10 mL acetic acid at room temperature.
^b Isolated yields.

ISSN: 2661-801X