Novel enaminone derived from thieno [2,3-b] thiene: Synthesis, x-ray crystal structure, HOMO, LUMO, NBO analyses and biological activity

Table 7 Antimicrobial activity of compound 5 (Zone of inhibition; diameter in mm

Compd.	Fungi		Gram (+) bacteria		Gram (−) bacteria
Compd.	(A)	(B)	(C)	(D)	(E)	(F)
SD	23.7 ± 0.1	25.4 ± 0.1	23.8 ± 0.2	32.4 ± 0.3	17.3 ± 0.1	19.9 ± 0.3
5	17.3 ± 0.44	16.9 ± 0.25	16.3 ± 0.55	18.3 ± 0.25	NA	NA

ST=25 μg/mL. (A): Aspergillus fumigatus; (B): Saccharomyces cerevisiae; (C): Staphylococcus aureus; (D): Bacilils subtilis; (E): Pseudomonas aeruginosa; (F): Escherichia coli. NA: Not Active. The test was performed three times for each bacterium. Streptomycin and Clotrimazole were used as antibacterial and antifungal standard drugs respectively.

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