Table 4 Pharmacokinetic data of galangin after administration to rats (n = 3)
From: Differential systemic exposure to galangin after oral and intravenous administration to rats
PK parameters | i.v. administration | p.o. administration |
|---|---|---|
(2 mg/kg) | (10 mg/kg) | |
Free type of galangin | ||
C max or C 5min (ng/mL) | 1456 + 802 | 219 ± 207 |
T max (h) | 0.083 | 0.083 |
AUC0-t (h•ng/mL) | 265 ± 176 | 48.7 ± 44.1 |
AUC0-∞ (h ng/mL-1) | 271 ± 179 | 80.8 ± 40.5 |
t 1/2 (h) | 0.21 ± 0.02 | - |
MRT (h) | 0.18 ± 0.01 | 1.28 ± 1.75 |
CLtot, p (L•h/kg) | 6.86 ± 3.32 | - |
V ss (L/kg) | 1.20 ± 0.55 | - |
F (%) | - | 3.67 ± 3.33 |
Hydrolyzed type of galangin after enzyme hydrolysis treatment | ||
C max or C 5min (ng/mL) | 2273 + 265 | 5103 ± 829 |
T max (h) | 0.083 | 0.083, 2 |
AUC0-t (h ng/mL) | 1169 ± 360 | 22184 ± 4482 |
AUC0-∞ (h ng/mL-1) | 1188 ± 339 | 22214 ± 4482 |
t 1/2 (h) | 1.37 ± 0.69 | - |
MRT (h) | 1.19 ± 0.51 | 4.03 ± 1.09 |
CLtot, p (L•h/kg) | 1.59 ± 0.47 | - |
V ss (L/kg) | 1.73 ± 0.42 | - |
F (%) | - | 380 ± 77 |