Skip to main content

Advertisement

Table 1 Synthesis of 2-(bromomethyl)-5-aryl-thiophenes (3a-i)

From: Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules

3 Aryl/ArylBoronic acids Products Solvent/H 2O (4:1) Yield %
a 3-Cl-4-F-C6H3 1,4-Dioxane 65
b 4-MeO-C6H4 1,4-Dioxane 76
c 4-Cl-C6H4 1,4-Dioxane 63
d 3,5-F2-C6H3 1,4-Dioxane 61
e 3-(MeCO)-C6H4 1,4-Dioxane 63
f 4-(MeS)-C6H4 1,4-Dioxane 56
g 4-I-C6H4 1,4-Dioxane 60
h 4-Me-C6H4 1,4-Dioxane 53
i 3,5-Me2C6H3 1,4-Dioxane 70