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Table 1 Synthesis of 2-(bromomethyl)-5-aryl-thiophenes (3a-i)

From: Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules

3

Aryl/ArylBoronic acids

Products

Solvent/H 2O (4:1)

Yield %

a

3-Cl-4-F-C6H3

1,4-Dioxane

65

b

4-MeO-C6H4

1,4-Dioxane

76

c

4-Cl-C6H4

1,4-Dioxane

63

d

3,5-F2-C6H3

1,4-Dioxane

61

e

3-(MeCO)-C6H4

1,4-Dioxane

63

f

4-(MeS)-C6H4

1,4-Dioxane

56

g

4-I-C6H4

1,4-Dioxane

60

h

4-Me-C6H4

1,4-Dioxane

53

i

3,5-Me2C6H3

1,4-Dioxane

70