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Table 2 Summary of assay validation results

From: Hair-based rapid analyses for multiple drugs in forensics and doping: application of dynamic multiple reaction monitoring with LC-MS/MS

Drugs in (pg/mg) Conctrn. QC's Linear range LOD r 2 Inra-day (n = 6) Inter-day(n = 6)
Precision, % CV Accuracy,% Precision, % CV Accuracy,%
Nandrolone 10 0.1-100 0.05 0.9998 3.23 100.1 4.82 99.8
25 1.96 100.4 1.95 99.4
50 1.41 99.9 1.39 100.2
Stanozolol 10 0.1-100 0.05 0.9995 6.3 102.1 9.4 101.2
25 10.2 98.5 7.1 99.8
50 8.6 99.4 3.2 101.3
Boldenone 10 0.5-100 0.25 0.9998 4.9 99.9 3.4 101.1
25 3.3 100.3 2.7 99.8
50 2.5 99.7 2.3 98.7
Cocaine 10 0.5-100 0.25 0.9998 3.5 98.9 3.2 99.8
25 4.3 99.4 3.3 98.9
50 2.9 99.9 2.3 97.8
Benzoylecgonine 10 0.5-100 0.25 0.9987 3.5 107.2 4.7 100.5
25 2.1 102.3 10.9 102.6
50 3.3 100.1 8.9 99.9
Amphetamine 10 0.25-100 0.1 0.9979 7.1 98.8 3.2 100.5
25 5.9 99.6 2.7 100.1
50 3.2 89.9 3.2 100.3
Methamphetamine 10 0.5-100 0.25 0.9988 5.2 98.3 5.3 100.2
25 2.3 102.6 2.1 103.3
50 4.1 100.9 3.6 108.1
Ephedrine 10 1-100 0.5 0.9945 3.8 99.3 4.3 101.2
25 3.5 98.7 2.1 99.8
50 3.2 101.2 3.2 99.9
MDMA 10 0.5-100 0.25 0.9968 5.1 99.4 5.1 100.3
25 2.4 103.2 3.3 110.2
50 3.7 101.6 6.2 104.2
THC 10 1-100 0.5 0.9996 2.1 107.3 4.3 109.2
25 3.2 110.2 2.6 105.3
50 5.1 101.3 3.9 103.2
THC-COOH 10 1-100 0.5 0.9992 4.3 100.1 3.3 101.1
25 3.6 98.9 3.9 99.9
50 2.9 98.6 4.3 98.9
11-OH-THC 10 0.5-100 0.25 0.9998 3.6 89.8 5.3 90.5
25 2.1 89.9 5.9 89.6
50 5.3 90.9 2.1 99.8
Morphine 10 0.5-100 0.25 0.999 4.2 89.3 3.2 90.9
25 6.3 88.9 5.3 91.8
50 3.9 100.9 2.1 99.5
Codeine 10 0.5-100 0.25 0.999 2.9 98.9 1.9 99.5
25 8.3 99.5 5.6 99.3
50 2.4 99.3 1.5 9.8
Clenbuterol 10 0.5-100 0.25 0.9989 5.1 114.2 4.6 104.3
25 2.1 89.9 1.3 103.4
50 1.2 99.9 1.3 105.6
Salbutamol 10 1-100 0.5 0.9998 2.1 99.9 1.9 102.3
25 1.9 98.4 1.8 101.2
50 3.2 100.5 2.1 101.1
Propranolol 10 0.1-100 0.05 0.9999 2.2 99.7 1.9 100.5
25 2.6 89.9 2.5 99.78
50 1.1 98.9 1.5 98.5
Terbutaline 10 0.5-100 0.25 0.9997 1.7 100.8 1.9 99.9
25 1.2 99.9 2.1 100.5
50 2.2 100.5 1.9 102.3
PCP 10 0.5-100 0.25 0.9998 1.4 102.3 2 100.3
25 2.1 101.3 3.5 100.1
50 3.2 105.1 1.5 100.5
Ketamine 10 0.5-100 0.25 0.9996 1.6 104.2 1.1 98.9
25 2.6 102.3 2.1 99.9
50 2.4 104.2 2.2 99.6