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Table 2 Main pharmacokinetic parameters of columbianadin in rats after intravenous three doses of 1, 2.5 and 5 mg kg −1 , respectively

From: LC–MS/MS determination and pharmacokinetic study of columbianadin in rat plasma after intravenous administration of pure columbianadin

Parameters

Low

Media

High

T1/2α(h)

0.027 ± 0.016

0.060 ± 0.065

0.028 ± 0.023

T1/2β(h)

0.58 ± 0.20

0.52 ± 0.25

0.52 ± 0.22

Cmax(μg/L)

1253 ± 809

2741 ± 1005

4653 ± 2628

AUC(0-tn)(μg/Lh)

459 ± 346

563 ± 124

1294 ± 513

AUC(0-∞)(μg/Lh)

478 ± 365

593 ± 113

1344 ± 529

MRT(0-tn)(h)

1.03 ± 0.19

0.65 ± 0.10

1.22 ± 0.61

MRT(0-∞)(h)

1.28 ± 0.23

0.85 ± 0.25

1.62 ± 0.89

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BMC Chemistry

ISSN: 2661-801X

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