Nature of stress | Storage conditions | Time (h) | Amount of pheniramine | Amount of naphazoline hydrochloride | Extent of decomposition |
---|---|---|---|---|---|
Remaining ± SD (%) | Remaining ± SD (%) | ||||
5 M HCl | 40°C | 24 | 93.4 ± 0.7 | 80.2 ± 0.4 | Substantial |
5 M NaOH | 40°C | 2 | 61.3 ± 1.0 | 48.7 ± 1.6 | Substantial |
6% H2O2 | 40°C | 24 | 87.8 ± 2.3 | 72.1 ± 1.8 | Substantial |
Thermal | 40°C | 120 | 99.2 ± 1.1 | 101.4 ± 1.4 | None |
40°C | 240 | 98.5 ± 1.4 | 93.3 ± 1.8 | Substantial | |
Dry heat | 105°C | 7 | 98.6 ± 2.4 | 65.7 ± 2.5 | Substantial |
Photolytic | 1.2 million lux hours and 200 W h/m2 | 97.6 ± 1.9 | 98.6 ± 2.3 | None |