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Table 5 Robustness of naphazoline hydrochloride

From: A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations

Chromatographic condition Assay % tR (min) Theoretical plates Symmetry
Flow rate (0.9 mL min-1) 101.5 6.565 6534 0.91
Flow rate (1 mL min-1) 99.9 6.154 6745 0.93
Flow rate (1.1 mL min-1) 103.6 5.331 6521 0.88
Buffer: Methanol (70:30) 99.7 6.944 6346 0.90
Buffer: Methanol (68:32) 99.2 6.154 6351 0.89
Buffer: Methanol (65:35) 98.1 5.681 6566 0.86
Buffer (pH 2.6) 100.9 5.764 6812 0.85
Buffer (pH 2.8) 101.4 6.148 6745 0.89
Buffer (pH 3.0) 100.2 6.145 6625 0.87