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Table 4 Robustness of pheniramine

From: A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations

Chromatographic condition

Assay %

tR(min)

Theoretical plates

Symmetry

Flow rate (0.9 mL min-1)

103.4

3.734

6623

0.89

Flow rate (1 mL min-1)

101.2

3.013

6762

0.90

Flow rate (1.1 mL min-1)

99.5

2..910

6745

0.91

Buffer: Methanol (70:30)

99.2

4.136

6612

0.87

Buffer: Methanol (68:32)

100.7

3.013

6523

0.88

Buffer: Methanol (65:35)

99.6

2.956

6524

0.86

Buffer (pH 2.6)

101.7

2.990

6456

0.92

Buffer (pH 2.8)

101.9

3.073

6346

0.85

Buffer (pH 3.0)

100.9

3.360

6678

0.86