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Table 4 Robustness of pheniramine

From: A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations

Chromatographic condition Assay % tR(min) Theoretical plates Symmetry
Flow rate (0.9 mL min-1) 103.4 3.734 6623 0.89
Flow rate (1 mL min-1) 101.2 3.013 6762 0.90
Flow rate (1.1 mL min-1) 99.5 2..910 6745 0.91
Buffer: Methanol (70:30) 99.2 4.136 6612 0.87
Buffer: Methanol (68:32) 100.7 3.013 6523 0.88
Buffer: Methanol (65:35) 99.6 2.956 6524 0.86
Buffer (pH 2.6) 101.7 2.990 6456 0.92
Buffer (pH 2.8) 101.9 3.073 6346 0.85
Buffer (pH 3.0) 100.9 3.360 6678 0.86