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Table 1 Intraday and interday precision and accuracy of linifanib in rat plasma

From: Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS

Nominal concentration (ng/mL) Run    Rat plasma  
   Mean ± SD Precision (% CV) Accuracy (%)
Intraday variation (six replicate at each concentration)
0.45 1 0.48 ± 0.05 10.4 107.0
  2 0.47 ± 0.05 10.6 104.4
  3 0.49 ± 0.05 10.2 108.9
1.28 1 1.35 ± 0.14 10.4 105.3
  2 1.38 ± 0.14 10.1 105.0
  3 1.35 ± 0.08 5.9 105.6
42.5 1 44.5 ± 3.28 7.4 104.6
  2 39.7 ± 3.58 9.0 93.5
  3 40.2 ± 1.56 3.9 94.6
425 1 397 ± 36.4 9.2 93.5
  2 387 ± 12.2 3.2 90.9
  3 398 ± 13.5 3.4 93.9
Interday variation (18 replicates at each concentration)
0.45   0.48 ± 0.05 10.4 106.8
1.28   1.36 ± 0.09 6.6 106.3
42.5   41.48 ± 3.53 8.5 97.6
425   394 ± 22.79 5.8 92.8