Table 1 Intraday and interday precision and accuracy of linifanib in rat plasma
Nominal concentration (ng/mL) | Run | Rat plasma | ||
|---|---|---|---|---|
Mean ± SD | Precision (% CV) | Accuracy (%) | ||
Intraday variation (six replicate at each concentration) | ||||
0.45 | 1 | 0.48 ± 0.05 | 10.4 | 107.0 |
2 | 0.47 ± 0.05 | 10.6 | 104.4 | |
3 | 0.49 ± 0.05 | 10.2 | 108.9 | |
1.28 | 1 | 1.35 ± 0.14 | 10.4 | 105.3 |
2 | 1.38 ± 0.14 | 10.1 | 105.0 | |
3 | 1.35 ± 0.08 | 5.9 | 105.6 | |
42.5 | 1 | 44.5 ± 3.28 | 7.4 | 104.6 |
2 | 39.7 ± 3.58 | 9.0 | 93.5 | |
3 | 40.2 ± 1.56 | 3.9 | 94.6 | |
425 | 1 | 397 ± 36.4 | 9.2 | 93.5 |
2 | 387 ± 12.2 | 3.2 | 90.9 | |
3 | 398 ± 13.5 | 3.4 | 93.9 | |
Interday variation (18 replicates at each concentration) | ||||
0.45 | 0.48 ± 0.05 | 10.4 | 106.8 | |
1.28 | 1.36 ± 0.09 | 6.6 | 106.3 | |
42.5 | 41.48 ± 3.53 | 8.5 | 97.6 | |
425 | 394 ± 22.79 | 5.8 | 92.8 | |