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Table 1 Rearrangements of pyrazolin-5-ones 1 and their isomers 2

From: N-heteroatom substitution effect in 3-aza-cope rearrangements

# Pyrazolinones 1 & isomers 2 Conditions temp./time Products yielda(%)
1 1a: R = Me 180°C / 60 m 4a: R = Me (35)
2 1b: R = Ph 180°C / 10 m 4b: R = Ph (72)
3 2a: R = Me 180°C / 10 m 4a: R = Me (90)
4 2b: R = Ph 180°C / 10 m 4b: R = Ph (99)
5 5a: R = Me 180°C / 30 m 6a: R = Me (30)
6 7a: R = Me 180°C / 10 m 6a: R = Me (80)
  1. aIsolated yields after flash-chromatography.