Stress degradation studies and stability-indicating TLC-densitometric method of glycyrrhetic acid

BMC Chemistry

Table 4 Summary of stress degradation studies of glycyrrhetic acid

Degradation conditions	Time (hour)	R_fof degraded products	Compound remained (ng /1000ng±S.D., n=3)	% Recovery
Acidic hydrolysis ^a
1N HCl	2	0.08, 0.1,0.64	362.19±7.7	36.21
5N HCl	2	0.08,0.1, 0.12, 0.64	253.83±1.5	25.38
Basic hydrolysis ^a
0.1N NaOH	2	Not detected	999.9±5.2	99.9
1N NaOH	2	Not detected	892.9±11	89.2
5N NaOH	2	Not detected	-	100^b
Oxidation
35%v/v H₂O₂^a	2	Not detected	993.07±5.5	99.3
Oxidation at room temp	24	Not detected	987.8±6.4	98.7
Neutral hydrolysis ^a	2	Not detected	997.09±7.7	99.7
Wet heating ^a	2	Not detected	999.47±9.5	99.9
Dry heating	4	Not detected	999.58±6.2	99.9
Photostability- daylight	24	0.35,0.38,0.49	663.74±5.1	66.3

ISSN: 2661-801X