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Table 4 Summary of stress degradation studies of glycyrrhetic acid

From: Stress degradation studies and stability-indicating TLC-densitometric method of glycyrrhetic acid

Degradation conditions Time (hour) Rfof degraded products Compound remained (ng /1000ng±S.D., n=3) % Recovery
Acidic hydrolysis a     
1N HCl 2 0.08, 0.1,0.64 362.19±7.7 36.21
5N HCl 2 0.08,0.1, 0.12, 0.64 253.83±1.5 25.38
Basic hydrolysis a     
0.1N NaOH 2 Not detected 999.9±5.2 99.9
1N NaOH 2 Not detected 892.9±11 89.2
5N NaOH 2 Not detected - 100b
Oxidation     
35%v/v H2O2a 2 Not detected 993.07±5.5 99.3
Oxidation at room temp 24 Not detected 987.8±6.4 98.7
Neutral hydrolysis a 2 Not detected 997.09±7.7 99.7
Wet heating a 2 Not detected 999.47±9.5 99.9
Dry heating 4 Not detected 999.58±6.2 99.9
Photostability- daylight 24 0.35,0.38,0.49 663.74±5.1 66.3
  1. aReflux in parallel synthesizer at 80°C.
  2. bRecover in salt form.