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Table 1 Intra- and inter-day precision and accuracy of LND in rabbit and human plasma

From: Development and validation of ultra-performance liquid chromatographic method with tandem mass spectrometry for determination of lenalidomide in rabbit and human plasma

Nominal conc. (ng/mL)

Run

Rabbit plasma

Human plasma

  

Measured conc. (ng/mL ± SD)

Precision (CV,%)

Accuracy (recovery,%)

Measured conc. (ng/mL ± SD)

Precision (CV,%)

Accuracy (recovery,%)

 

Intraday variation (six replicate at each concentration)

0.26

1

0.27 ± 0.02

6.98

103

0.29 ± 0.01

3.60

110

 

2

0.26 ± 0.03

9.51

101

0.29 ± 0.03

9.61

109

 

3

0.28 ± 0.03

12.2

108

0.30 ± 0.03

9.53

113

1.28

1

1.30 ± 0.07

6.74

101

1.32 ± 0.08

5.80

103

 

2

1.32 ± 0.04

3.09

103

1.34 ± 0.05

3.51

105

 

3

1.36 ± 0.06

4.78

106

1.37 ± 0.06

4.16

107

64.0

1

59.3 ± 5.35

9.02

92.7

59.8 ± 5.95

9.94

93.5

 

2

64.8 ± 4.26

6.57

101

64.8 ± 5.42

8.36

101

 

3

58.5 ± 6.19

10.60

91.4

63.8 ± 5.91

9.26

99.7

800

1

832 ± 17.70

2.14

104

814 ± 43.60

5.36

102

 

2

778 ± 19.30

2.48

97.2

790 ± 34.50

4.37

98.8

 

3

775.8 ± 38.60

4.97

97.0

769 ± 15.10

1.97

96.1

 

Intraday variation (18 replicates at each concentration)

0.26

 

0.27 ± 0.03

9.67

104

0.29 ± 0.03

9.72

111

1.28

 

1.32 ± 0.06

4.80

103

1.34 ± 0.06

4.54

105

64

 

60.9 ±5.80

9.49

95.1

62.9 ± 5.91

9.40

98.3

800

 

795 ±36.80

4.62

99.4

791 ± 36.60

4.62

99.2