Scheme 1
From: Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole
Synthetic route to nicotinamide derivatives containing 1,3,4-oxadiazole.
Synthetic route to nicotinamide derivatives containing 1,3,4-oxadiazole. Reagents and conditions: (a). KOH, EtOH, CS2, reflux; (b). BrCN, KHCO3, THF, rt; (c). KOH, Me2SO4, H2O. (d). (AcO)2O, reflux; (e). 2,2-dimethoxy-N,N-dimethylethenamine, EtOH, reflux.