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Table 3 The comparative IC 50 (μgmL -1 ) effect of gatifloxacin and test compounds on oxidative burst of whole blood, isolated PMNs, and mouse peritoneal macrophages

From: Identification of anti-inflammatory and other biological activities of 3-carboxamide, 3-carbohydrazide and ester derivatives of gatifloxacin

Compound Whole blood PMNs Macrophages
Gatifloxacin > 30 > 30 > 30
5 <<12.5 <<0.1 24.5 ± 5.6
7 <<12.5 <0.1 <3.1
15 <12.5 1.7 ± 0.6 8.5 ± 0.6
16 <<12.5 0.2 ± 0.1 7.6± 0.6
17 <<12.5 2.4 ± 1.0 12.9 ± 0.2
20 <12.5 0.2 ± 0.1