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Table 3 The comparative IC 50 (μgmL -1 ) effect of gatifloxacin and test compounds on oxidative burst of whole blood, isolated PMNs, and mouse peritoneal macrophages

From: Identification of anti-inflammatory and other biological activities of 3-carboxamide, 3-carbohydrazide and ester derivatives of gatifloxacin

Compound

Whole blood

PMNs

Macrophages

Gatifloxacin

> 30

> 30

> 30

5

<<12.5

<<0.1

24.5 ± 5.6

7

<<12.5

<0.1

<3.1

15

<12.5

1.7 ± 0.6

8.5 ± 0.6

16

<<12.5

0.2 ± 0.1

7.6± 0.6

17

<<12.5

2.4 ± 1.0

12.9 ± 0.2

20

<12.5

0.2 ± 0.1

–

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BMC Chemistry

ISSN: 2661-801X

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