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Table 1 Screening of gatifloxacin and its derivatives for chemiluminescence activity using whole blood

From: Identification of anti-inflammatory and other biological activities of 3-carboxamide, 3-carbohydrazide and ester derivatives of gatifloxacin

Compound RLU Reading Inhibition% IC50 ± S.D
concentration (μg mL-1) 100 50 12.5 100 50 12.5  
4 1859.3 1831.4 1540.9 −75.16 −72.53 −45.16 >100
5 74.7 127.7 378.3 92.96 87.97 64.36 <12.5
6 172.8 435.2 873.8 83.72 59 17.68 39.3 ± 12.3
7 −1.7 −1.1 5 100.16 100.1 99.53 <12.5
8 200.5 402.6 905.1 81.11 62.08 14.73 34.6 ± 9.8
9 777.9 939.1 945.2 26.72 11.53 10.96 >100
10 306.9 736.1 1520 71.09 30.66 −43.18 69.6 ± 1.9
11 823.7 958.1 1129 22.41 9.74 −6.39 >100
12 1028.5 970.8 1334 3.11 8.55 −25.72 >100
13 503.6 705.5 1060 52.56 33.54 0.13 90.7 ± 13.2
14 74.3 219.6 663.1 93.01 79.31 37.53 21.5 ± 6.7
15 109.6 222.1 444.6 89.68 79.08 58.12 <12.5
16 15.7 23.1 71.7 98.52 97.82 93.25 <12.5
17 20.5 48.3 226.7 98.07 95.45 78.64 <12.5
18 637.3 879.9 1199.9 39.96 17.11 −13.03 >100
19 379.6 676.6 1047.4 64.24 36.26 1.33 73.6 ± 0.4
20 99.5 143.6 389.8 90.62 86.47 63.28 <12.5
Gatifloxacin 162.4 360.6 852.1 84.7 66.03 19.73 31 ± 0