Synthesis and characteristics of (Hydrogenated) ferulic acid derivatives as potential antiviral agents with insecticidal activity

Table 1 In vivo insecticidal activities and antiviral activities of the investigated compounds

Compd.	R²	R¹	R³	Insecticidal activities			Anti-TMV activities
				A. fabae Scopoli	T. cinnabarinus	C. pipiens pallens	Protection effect	Curative effect
				200 μg/mL	200 μg/mL	2 μg/mL	500 μg/mL	500 μg/mL
7a	H	n-Pr	propynyl	78	70	30	40.7	46.4
7b	p-Cl	Me	Me	90	70	70	32.4	37.2
7c	p-Cl	Me	Et	48	50	60	0	18.6
7d	p-Cl	Me	propynyl	81	70	10	24.8	39.5
7e	p-Cl	Me	allyl	70	0	60	0	28.5
7f	p-Cl	Me	benzyl	92	60	10	0	0
7g	p-Cl	n-Pr	Me	0	0	40	24.3	27.7
7h	p-Cl	n-Pr	Et	70	70	30	5.3	12.6
7i	p-Cl	n-Pr	n-Pr	20	20	40	11.3	30.7
7j	p-Cl	n-Pr	propynyl	50	60	100	0	0
7k	p-Cl	n-Pr	allyl	71	75	60	0	5.6
7l	p-Cl	n-Pr	benzyl	0	50	50	13.4	0
7m	p-Cl	propynyl	Me	20	30	30	34.2	36.9
7n	p-Cl	propynyl	propynyl	0	0	60	21	22.7
7o	p-Cl	allyl	allyl	0	0	40	-^a	-
7p	p-Cl	benzyl	benzyl	0	0	60	17.5	23.8
13a	H	Me	benzyl	0	0	-	7.8	23.5
13b	p-Cl	Me	propynyl	0	0	-	27.3	30.4
13c	p-Cl	Me	benzyl	0	0	-	0	7.6
13d	p-Cl	n-Pr	Me	57	50	10	20.6	25.2
13e	p-Cl	n-Pr	Et	18	10	40	17.3	0
13f	p-Cl	n-Pr	propynyl	91	70	30	12.9	10.2
13g	p-Cl	n-Pr	allyl	58	25	40	16.5	12.7
13h	p-Cl	n-Pr	benzyl	92	75	50	27.6	21.6
13i	p-Cl	propynyl	propynyl	42	30	40	14.5	19.6
chlorfenapyr				100	100	100	-	-
Ribavirin				-	-	-	32.6	38.5

ISSN: 2661-801X