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Table 1 Yields of compound 4i at different reaction conditions

From: Synthesis, antifungal and antibacterial activity for novel amide derivatives containing a triazole moiety

Entry

Solvent

Time/h

Acid binding agent

Temperature/°C

Yield/%

1

Tetrahydrofuran

8

Potassium carbonate

50

73.8

2

Toluene

8

Potassium carbonate

50

15.3

3

Acetonitrile

8

Potassium carbonate

50

22.1

4

Dichloromethane

8

Potassium carbonate

50

40.0

5

Tetrahydrofuran

8

Triethylamine

50

33.6

6

Tetrahydrofuran

8

Pyridine

50

55.4

7

Tetrahydrofuran

4

Potassium carbonate

50

62.5

8

Tetrahydrofuran

6

Potassium carbonate

50

67.8

9

Tetrahydrofuran

10

Potassium carbonate

50

76.4

10

Tetrahydrofuran

8

Potassium carbonate

25

60.1

11

Tetrahydrofuran

10

Potassium carbonate

25

62.2