Application of smart spectrophotometric methods and artificial neural network for the simultaneous quantitation of olmesartan medoxamil, amlodipine besylate and hydrochlorothiazide in their combined pharmaceutical dosage form

Table 4 Determination of AML, OLM and HCT in laboratory prepared mixtures by the proposed methods

Concentration (μg mL^-1)			Spectrophotometric methods				ANN method
			Direct	Isoabsorptive	Ratio subtraction		ANN method
			Recovery % ^a
AML	OLM	HCT	AML	OLM	HCT	AML	OLM	HCT
7	25	10	101.56	101	101.81	101.62	98.2	102.56
5	15	13.75	98.55	100.36	103.8	101.05	100.01	101.2
6	15	10	97.27	98	103.54	100.07	97.28	100.01
7	15	11.25	98.96	100.2	103.03	102.44	101.84	102.58
7	17.5	12.5	101.56	102.26	100.89	99.55	98.11	100
5	17.5	10	102.18	100.52	102.22	100.75	100.35	100.89
6	17.5	15	100.30	100.66	103.73	101.93	101.89	100
5	20	12.5	100.36	97.71	102.06	101.34	100.99	100.35
6	20	13.75	100.91	98.82	101.34	101.22	99.9	100.47
Mean			100.18	99.24	101.89	101.11	99.84	100.90
SD			1.620	2.312	0.595	0.895	1.660	1.035
RSD%			1.617	2.33	0.584	0.885	1.663	1.026

ISSN: 2661-801X