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Table 1 Experimental designs and the results of CCD

From: Ultrasound-assisted lipase-catalyzed synthesis of D-isoascorbyl palmitate: process optimization and Kinetic evaluation

Run A(X1)a B( X2)b C(X3)c D(X4)d Conversion rate (%)
I II Average predicted
1 -1 -1 -1 -1 49.00 37.50 38.25 ± 1.06 40.81
2 1 -1 -1 -1 49.77 47.47 48.62 ± 1.63 49.85
3 -1 1 -1 -1 70.77 67.95 69.36 ± 2.00 69.55
4 1 1 -1 -1 72.66 69.04 70.85 ± 2.56 73.65
5 -1 -1 1 -1 45.99 34.31 40.15 ± 8.26 46.72
6 1 -1 1 -1 51.90 56.00 53.95 ± 2.90 57.31
7 -1 1 1 -1 77.98 77.50 77.74 ± 0.34 75.84
8 1 1 1 -1 81.98 79.62 80.8 ± 1.68 81.80
9 -1 -1 -1 1 60.21 56.53 58.37 ± 2.60 61.21
10 1 -1 -1 1 66.99 71.85 69.42 ± 3.44 73.48
11 -1 1 -1 1 76.09 78.47 77.28 ± 1.69 76.08
12 1 1 -1 1 85.99 86.91 86.45 ± 0.65 83.42
13 -1 -1 1 1 65.33 70.65 67.99 ± 3.76 67.34
14 1 -1 1 1 76.00 79.62 77.81 ± 2.55 81.86
15 -1 1 1 1 82.98 77.58 80.28 ± 3.83 82.59
16 1 1 1 1 90.09 93.69 91.89 ± 2.55 91.48
17 -2 0 0 0 62.90 56.84 59.87 ± 4.29 57.35
18 2 0 0 0 78.90 78.02 78.46 ± 0.63 75.27
19 0 -2 0 0 56.09 63.65 59.87 ± 5.34 51.05
20 0 2 0 0 88.98 85.02 87.00 ± 2.80 90.11
21 0 0 -2 0 70.02 60.50 65.26 ± 6.73 63.39
22 0 0 2 0 80.99 81.39 81.19 ± 0.28 77.36
23 0 0 0 -2 63.60 57.30 60.45 ± 4.45 55.54
24 0 0 0 2 85.99 87.43 86.71 ± 1.02 85.07
25 0 0 0 0 56.99 59.93 58.46 ± 2.07 58.43
26 0 0 0 0 58.46 59.45 58.95 ± 0.07 58.43
27 0 0 0 0 60.09 56.83 58.46 ± 2.31 58.43
28 0 0 0 0 58.46 57.51 57.98 ± 0.67 58.43
29 0 0 0 0 60.82 55.18 58.00 ± 3.99 58.43
30 0 0 0 0 58.46 59.01 58.73 ± 0.39 58.43
  1. a: X1:Temperature; b: X2: Molar ratio (D-isoascorbic: palmitic acid);
  2. c: X3: Enzyme load; d: X4: Ultrasound power.