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Table 1 In vitro cytotoxicities against four different tumor cell lines

From: Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents

Compound       IC50(nM)  
  MDA-MB-231 MCF-7 K562 A549
CA-4 6.27 10.49 5.75 428
6 12.29 8.00 7.68 693
7(CA-4E) 2.30 1.32 <2.50 180
8a 7.26 8.38 14.78 486
8b 7.77 7.59 14.88 476
9a 7.94 10.04 14.90 309
9b 6.68 11.29 8.76 330
10 6.40 10.39 9.42 435
11 4.39 12.46 12.28 316
12 7.27 7.09 8.85 265
13 12.23 10.85 9.65 735
14 39.60 66.09 80.84 >1000