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Table 4 Content of toxic alkaloids in various processed and unprocessed samples of Aconitum roots

From: A comparative study on the traditional Indian Shodhana and Chinese processing methods for aconite roots by characterization and determination of the major components

Sample Aconitine Mesaconitine Hypaconitine
(mg/kg) (mg/kg) (mg/kg)
*Mean ± S. D. *Mean ± S. D. *Mean ± S. D.
A . heterophyllum
Unprocessed drug material 11.310 ± 0.629 9.680 ± 0.327 13.760 ± 0.022
Drug processed with Cow milk 1.050 ± 0.146 1.964 ± 0.504 0.943 ± 0.016
Filtrate of cow milk decoction 0.274 ± 0.052 1.085 ± 0.62 0.361 ± 0.058
Drug processed with Cow urine 4.700 ± 0.034 2.127 ± 0.433 3.284 ± 0.856
Filtrate of cow urine extraction 5.209 ± 1.426 2.985 ± 0.798 4.076 ± 065
Drug processed with water 1.900 ± 0.002 0.962 ± 0.275 0.119 ± 0.032
Filtrate of aqueous decoction 2.198 ± 0.968 1.086 ± 0.724 0.212 ± 0.105
A . carmichaelii
Unprocessed drug material 16.265 ± 0.082 15.305 ± 0.605 16.245 ± 0.538
Drug processed with Cow milk 2.078 ± 0.002 1.047 ± 0.748 1.797 ± 0.049
Filtrate of cow milk decoction 4.284 ± 0.440 1.288 ± 0.249 1.039 ± 0.138
Drug processed with Cow urine 5.536 ± 0.008 3.518 ± 0.322 4.405 ± 0.122
Filtrate of cow urine extraction 1.361 ± 0.688 3.428 ± 0.127 6.177 ± 1.720
Drug processed with water 1.150 ± 0.445 1.729 ± 0.275 2.829 ± 0.007
Filtrate of aqueous decoction 2.615 ± 0.578 2.40 ± 0.775 3.174 ± 0.583
A . kusnezoffii
Unprocessed drug material 14.405 ± 0.386 14.150 ± 0.605 18.135 ± 0.229
Drug processed with Cow milk 3.960 ± 0.088 4.389 ± 0.060 1.720 ± 0.069
Filtrate of cow milk decoction 7.817 ± 1.707 8.502 ± 1.71 13.658 ± 4.21
Drug processed with Cow urine 11.125 ± 0.101 4.865 ± 0.220 3.088 ± 0.053
Filtrate of cow urine extraction 2.258 ± 0.231 6.689 ± 0.218 3.840 ± 0.33
Drug processed with water 2.050 ± 0.056 2.448 ± 0.150 1.067 ± 0.070
Filtrate of aqueous decoction 4.947 ± 1.749 4.086 ± 1.095 2.863 ± 0.817
  1. *(n = 3) for each of the values mentioned for the above determinations.