Scheme 2

Synthesis of the target compounds 5a-k. Reagents and conditions: i) NaBH4, methanol, rt, 24 h; 60-78% yield ii) Appropriate carboxylic acid, EDCI HCl, DMAP, DCM, rt, 18 h, 28-86% yield.
Synthesis of the target compounds 5a-k. Reagents and conditions: i) NaBH4, methanol, rt, 24 h; 60-78% yield ii) Appropriate carboxylic acid, EDCI HCl, DMAP, DCM, rt, 18 h, 28-86% yield.