Scheme 1
Synthesis of the ketones 3a-d. Reagents and conditions: i) HN(CH3)2HCl, (CH2O)n, conc. HCl, ethanol, reflux, 2 h; 47-95% yield ii) Imidazole, water, reflux, 5 h, 44-77% yield.
Scheme 1 | Chemistry Central Journal
Synthesis of the ketones 3a-d. Reagents and conditions: i) HN(CH3)2HCl, (CH2O)n, conc. HCl, ethanol, reflux, 2 h; 47-95% yield ii) Imidazole, water, reflux, 5 h, 44-77% yield.