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Table 6 Summary of stress degradation studies of stanozolol

From: A validated stability-indicating TLC-densitometric method for the determination of stanozolol in pharmaceutical formulations

Degradation conditions

% Recovery

% Degradation

Rfof degraded products

Acidic hydrolysis a

   

0.1N HCl

88.28

11.72

0.49, 0.55

1N HCl

76.25

23.75

0.49, 0.55

5N HCl

45.07

54.93

0.49, 0.55

Basic hydrolysis a

   

0.1N NaOH

98.40

1.60

Not detected

1N NaOH

95.19

4.81

Not detected

5N NaOH

90.71

9.29

Not detected

Neutral hydrolysis a

98.65

1.35

Not detected

Wet heating a

99.59

0.41

Not detected

Dry heating

98.32

1.68

Not detected

Oxidation a

   

5%v/v H2O2

97.90

2.10

Not detected

35%v/v H2O2

99.59

0.41

Not detected

Oxidation at room temp

98.30

1.70

Not detected

Photostability-daylight

98.62

1.38

Not detected

  1. aReflux in parallel synthesizer for two hours at 80°C.