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Table 6 Summary of stress degradation studies of stanozolol

From: A validated stability-indicating TLC-densitometric method for the determination of stanozolol in pharmaceutical formulations

Degradation conditions % Recovery % Degradation Rfof degraded products
Acidic hydrolysis a    
0.1N HCl 88.28 11.72 0.49, 0.55
1N HCl 76.25 23.75 0.49, 0.55
5N HCl 45.07 54.93 0.49, 0.55
Basic hydrolysis a    
0.1N NaOH 98.40 1.60 Not detected
1N NaOH 95.19 4.81 Not detected
5N NaOH 90.71 9.29 Not detected
Neutral hydrolysis a 98.65 1.35 Not detected
Wet heating a 99.59 0.41 Not detected
Dry heating 98.32 1.68 Not detected
Oxidation a    
5%v/v H2O2 97.90 2.10 Not detected
35%v/v H2O2 99.59 0.41 Not detected
Oxidation at room temp 98.30 1.70 Not detected
Photostability-daylight 98.62 1.38 Not detected
  1. aReflux in parallel synthesizer for two hours at 80°C.