Thermal behaviour of procaine and benzocaine Part II: compatibility study with some pharmaceutical excipients used in solid dosage forms

Table 2 Thermoanalytical data of active substances and their physical mixtures

Samples	HF		ΔH_fusion/J g^–1	DTG		Δm /%
Samples	T_{onset (fusion)}/°C	T_{peak (fusion)}/°C	ΔH_fusion/J g^–1	T_onset/°C	T_{peak DTG}/°C	Δm /%
Active substance
BZ	77;147	90;246	107.95	130	241	99.9
PR	148; 240	156; 279	110.47	194.5	281	90
Drug/excipient
BZ + MC	84; 161; 309	90; 204; 327	50.23	110	201	55; 45
BZ + L	77; 153	88; 196	48.52	87; 122	99; 195; 226	3; 52
BZ + MS	103	113.5	37.18	137	227	5; 50
BZ + T	78; 159	88; 222	54.70	120	220	50
PR + MC	146	154	50.89	173; 266	247; 280	65
PR + L	114	144	29.35	142; 226	191; 278	50
PR + MS	133	149	32.12	163	259	70
PR + T	144; 219	154; 263; 288	56.78	180	273	45

ISSN: 2661-801X