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Table 9 Compliance of acridone alkaloids with standard parameters of Lipinski’s rule of five for drug likeness and oral bioavailability

From: Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

Acridone alkaloids

miLOGP

MW

nON

nOHNH

nviolations

1

1.926

301.298

6

2

0

2

1.862

257.245

5

3

0

3

1.119

303.27

7

4

0

4

2.189

285.299

5

1

0

5

2.433

255.273

4

1

0

6

1.913

271.272

5

2

0

7

2.173

255.273

4

1

0

8

2.476

355.39

6

2

0

9

2.2

341.363

6

3

0

10

2.411

357.362

7

3

0

  1. miLogP = octanol/water partition coefficient, MW = molecular weight, nON = number of hydrogen acceptor, nOHNH = number of hydrogen donor, nviolations = violations from Lipinski’s rule.