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Table 9 Compliance of acridone alkaloids with standard parameters of Lipinski’s rule of five for drug likeness and oral bioavailability

From: Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

Acridone alkaloids miLOGP MW nON nOHNH nviolations
1 1.926 301.298 6 2 0
2 1.862 257.245 5 3 0
3 1.119 303.27 7 4 0
4 2.189 285.299 5 1 0
5 2.433 255.273 4 1 0
6 1.913 271.272 5 2 0
7 2.173 255.273 4 1 0
8 2.476 355.39 6 2 0
9 2.2 341.363 6 3 0
10 2.411 357.362 7 3 0
  1. miLogP = octanol/water partition coefficient, MW = molecular weight, nON = number of hydrogen acceptor, nOHNH = number of hydrogen donor, nviolations = violations from Lipinski’s rule.