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Table 7 Results of molecular docking experiments targeting anticancer protein uinine reductase (PDB: 3G5M) and aromatase (PDB: 3EQM)

From: Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

Molecule

H-bonds

Bound amino acid residues

Binding affinity (kcal/mol)

2

ASP-309, MET-374

-9.5

Androstenedione (control inhibitor)

02

PHE-17, THR-147

-5.8

6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin- 8(9 h)-one (Control inhibitor)

04

LEU-103, TYR-104, SER-107, GLY-149

-6.1

Compound 1

04

THR-148, TYR-155, SER-164

-6.7

Compound 8

06

PHE-106, THR-147, THR-148, TYR-155, SER-164

-7.3

Compound 9

03

LEU-103, PHE-106, THR-147

-7.7

Compound 10