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Table 5 Derived pharmacophore model for antibacterial activity of acridones against M. luteus

From: Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

Acridones

Score obtained

Categorizing through threshold (S = 4.1466)

Predicted activity

Experimental activity (MIC in μg/mL)

Experimental response

1.

4.668387

>4.1466

significantly active

>500

Non active

2.

4.655514

>4.1466

significantly active

Not tested

Not tested

3.

4.409138

>4.1466

significantly active

125

Active

4.

5.006913

>4.1466

significantly active

125

Active

5.

3.892896

<4.1466

Non-significant activity

Not tested

Not tested

6.

4.049106

<4.1466

Non-significant activity

Not tested

Not tested

7.

2.944231

<4.1466

Non-significant activity

500

Less active

8.

4.008224

<4.1466

Non-significant activity

>500

Non active

9.

4.189883

>4.1466

significantly active

Not tested

Not tested

10.

4.479721

>4.1466

significantly active

>500

Not active

  1. The threshold score (S) of 4.1466 has been selected for the screening of lead compounds.