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Table 5 Derived pharmacophore model for antibacterial activity of acridones against M. luteus

From: Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

Acridones Score obtained Categorizing through threshold (S = 4.1466) Predicted activity Experimental activity (MIC in μg/mL) Experimental response
1. 4.668387 >4.1466 significantly active >500 Non active
2. 4.655514 >4.1466 significantly active Not tested Not tested
3. 4.409138 >4.1466 significantly active 125 Active
4. 5.006913 >4.1466 significantly active 125 Active
5. 3.892896 <4.1466 Non-significant activity Not tested Not tested
6. 4.049106 <4.1466 Non-significant activity Not tested Not tested
7. 2.944231 <4.1466 Non-significant activity 500 Less active
8. 4.008224 <4.1466 Non-significant activity >500 Non active
9. 4.189883 >4.1466 significantly active Not tested Not tested
10. 4.479721 >4.1466 significantly active >500 Not active
  1. The threshold score (S) of 4.1466 has been selected for the screening of lead compounds.