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Table 4 Inhibition zone diameter (mm) of the tested chemicals that showed antimicrobial activities against the tested microorganisms

From: Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents

Compound No.

Inhibition zone diameter in mm ± (standard deviation)

E. coli

P. aeruginosa

B. subtilis

S. aureus

C. albicans

1a

20 (0.04)

0

23 (0.02)

12 (0.02)

34 (0.05)

2a

0

0

12 (0.04)

14 (0.10)

0

2c

0

0

12 (0.02)

10 (0.03)

0

2d

0

0

12 (0.03)

10 (0.07)

0

2e

0

0

11 (0.07)

8 (0.07)

0

2g

0

0

16 (0.04)

11 (0.05)

0

8a

0

0

30 (0.07)

0

0

8b

0

0

28 (0.10)

0

0

8c

0

0

23 (0.02)

0

0

8d

0

0

25 (0.09)

0

0

8e

0

0

29 (0.03)

0

0

8f

0

0

27 (0.10)

0

0

8h

0

0

26 (0.10)

0

0

10a

0

0

22 (0.20)

0

0

10b

0

0

25 (0.02)

0

0

10c

0

0

29 (0.20)

0

0

11b

0

0

13 (0.06)

6 (0.06)

 

12

0

0

11(0.10)

4 (0.04)

 

13a

0

0

16 (0.05)

0

0

13b

0

0

17 (0.10)

0

0

15a

0

0

19 (0.02)

12 (0.07)

0

15b

0

0

23 (0.03)

9 (0.2)

0

16

0

0

25 (0.09)

14 (0.02)

0

DMSO (solvent)

0

0

0

0

0

a Ampicillin

23 (0.14)

17 (0.07)

21 (0.05)

26 (0.07)

0

b Cycloheximide

-

-

-

-

0

  1. DMSO = Dimethyl sulfoxide, a Ampicillin antibacterial drug, b cycloheximide antifungal drug, – not tested.