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Table 3 Cytotoxicity a activities of compounds 7f and 7g in Vero and MRC-5 cells

From: Synthesis and structure−activity relationship of 8-substituted protoberberine derivatives as a novel class of antitubercular agents

Compd Vero   MRC-5  
  CC50 (ug/ml) SIb CC50 (ug/ml) SI
7f 14.72 ± 2.02 7.37 10.18 ± 2.78 5.09
7g 5.15 ± 1.29 10.3 8.78 ± 0.48 17.6
  1. a: Cytotoxic concentration required to inhibit Vero or MRC-5 cell growth by 50%.
  2. b: Selectivity index (SI) value equaled to CC50/MIC.