Compda | R1 | R2 | R3 | R4 | R5 | R6 | MICb | cLogPc |
---|---|---|---|---|---|---|---|---|
1 | > 128 | −0.77 | ||||||
2 | 128 | −1.08 | ||||||
3 | > 128 | −0.77 | ||||||
6a | PhOCH3-p | OCH2O | OCH3 | OCH3 | H | 32 | 0.35 | |
6b | PhOCH3-m | OCH2O | OCH3 | OCH3 | H | 16 | 0.35 | |
6c | PhCH3-p | OCH2O | OCH3 | OCH3 | H | 16 | 0.93 | |
6d | 1-naphthyl | OCH2O | OCH3 | OCH3 | H | 8 | 1.60 | |
6e | n-C10H21 | OCH2O | OCH3 | OCH3 | H | 2 | 3.29 | |
7a | PhOCH3-p | OCH2O | H | OCH3 | OCH3 | 4 | 0.35 | |
7b | PhOCH3-m | OCH2O | H | OCH3 | OCH3 | 2 | 0.35 | |
7c | PhCH3-p | OCH2O | H | OCH3 | OCH3 | 2 | 0.93 | |
7d | PhCl-p | OCH2O | H | OCH3 | OCH3 | 1 | 1.14 | |
7e | PhCl-m | OCH2O | H | OCH3 | OCH3 | 2 | 1.14 | |
7f | 1-naphthyl | OCH2O | H | OCH3 | OCH3 | 2 | 1.60 | |
7g | n-C10H21 | OCH2O | H | OCH3 | OCH3 | 0.5 | 3.29 | |
7h | n-C12H25 | OCH2O | H | OCH3 | OCH3 | 1 | 4.35 | |
8a | PhOCH3-p | OCH3 | OCH3 | OCH3 | OCH3 | H | 16 | 0.04 |
8b | PhOCH3-m | OCH3 | OCH3 | OCH3 | OCH3 | H | 16 | 0.04 |
8c | PhCH3-p | OCH3 | OCH3 | OCH3 | OCH3 | H | 16 | 0.62 |
8d | 1-naphthyl | OCH3 | OCH3 | OCH3 | OCH3 | H | 4 | 1.29 |
8e | n-C10H21 | OCH3 | OCH3 | OCH3 | OCH3 | H | 1 | 2.98 |
RIF | 0.0625 | 3.90 | ||||||
INH | 0.0625 | −1.12 |