TY - JOUR AU - Sun, Wen-Jing AU - Zhao, Hong-Xia AU - Cui, Feng-Jie AU - Li, Yun-Hong AU - Yu, Si-Lian AU - Zhou, Qiang AU - Qian, Jing-Ya AU - Dong, Ying PY - 2013 DA - 2013/07/08 TI - D-isoascorbyl palmitate: lipase-catalyzed synthesis, structural characterization and process optimization using response surface methodology JO - Chemistry Central Journal SP - 114 VL - 7 IS - 1 AB - Isoascorbic acid is a stereoisomer of L-ascorbic acid, and widely used as a food antioxidant. However, its highly hydrophilic behavior prevents its application in cosmetics or fats and oils-based foods. To overcome this problem, D-isoascorbyl palmitate was synthesized in the present study for improving the isoascorbic acid’s oil solubility with an immobilized lipase in organic media. The structural information of synthesized product was clarified using LC-ESI-MS, FT-IR, 1H and 13C NMR analysis, and process parameters for high yield of D-isoascorbyl palmitate were optimized by using One–factor-at-a-time experiments and response surface methodology (RSM). SN - 1752-153X UR - https://doi.org/10.1186/1752-153X-7-114 DO - 10.1186/1752-153X-7-114 ID - Sun2013 ER -