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Table 1 The yield of pyrazole derivative 5a obtained using various catalysts under ultrasonic irradiation

From: Ultrasonic irradiation assisted efficient regioselective synthesis of CF3-containing pyrazoles catalyzed by Cu(OTf)2/Et3N

Entry Catalyst Loading (mol%) Time (min.) Yields (%)
1 None - 180 No reaction
2 EtONa 100 60 Traces
3 Et3N 5 45 73
4 Et3N 10 45 67
5 Cu(OTf)2 5 60 No reaction
6 Cu(OTf)2 10 60 No reaction
7 Cu(OTf)2/ Et3N 5:5 45 90
8 Cu(OTf)2/ Et3N 10:5 60 90