Product | R | Ar-OH | H-5. | H-3, | H-6, | H-2, | ArCH2N | H-3a, | H-4, H-5 |
---|---|---|---|---|---|---|---|---|---|
H-5′ | H-3′ | H-6′ | H-2′ | H7a | H-6, H-7 | ||||
8a | F | 10.34, bs | 6.87, td, J = 8.0 Hz, J = 8.2 Hz, J = 3.1 Hz | 6.70, dd, J = 8.0 Hz, J = 2.8 Hz | 6.76, dd, J = 8.0 Hz, J = 4.8 Hz | 3.39,d, 3.84, d, J = 6.4 Hz | 3.63, d, 4.03, d, J = 14.0 Hz | 3.11, t, J = 4.0 Hz | 1.30-1.80, m |
8b | Cl | 10.63, bs | 7.15, dd, J = 8.6 Hz, J = 2.6 Hz | 6.97, d, J = 2.5 Hz | 6.78, d, J = 8.6 Hz | 3.39, d, 3.85, d J = 6.6 Hz | 3.64, d, 4.04, d J = 14.0 Hz | 3.11, t, J = 4.1 Hz | 1.30-1.80, m |
8c | Br | 10.55, bs | 7.26, dd, J = 8.6 Hz, J = 2.4 Hz | 7.09, d, J = 2.4 Hz | 6.72, d, J = 8.6 Hz | 3.36, d, 3.84, d J = 6.6 Hz | 3.62, d, 4.02, d, J = 13.9 Hz | 3.09, t, J = 4.0 Hz | 1.30-1.80, m |
8d | I | --- | 7.45, d, J = 8.8 Hz | 7.27, s | 6.62, d, J = 8.5 Hz | 3.62, d, 3.85, d, J = 8.0 Hz | 3.62, d, 4.01, d, J = 13.9 Hz | 3.11, t, J = 4.0 Hz | 1.30-1.80, m |
8e | (C = O)OMe (3.87, s) | 10.79, bs | 7.96, dd, J = 8.4 Hz, J = 2.1 Hz | 7.74, d, J = 2.1 Hz | 6.87, d, J = 8.8 Hz | 3.42, d, 3.85, d, J = 8.0 Hz | 3.67, d, 4.06, d, J = 14.0 Hz | 3.11, t, J = 4.0 Hz | 1.30-1.80, m |
8f | (C = O)OEt (1,35, t; 4,31, q) | ---- | 7.88, dd, J = 8.5 Hz, J = 2.1 Hz | 7.70, d, J = 2.0 Hz | 6.83, d, J = 8.5 Hz | 3.37, d, 3.86, d, J = 6.6 Hz | 3.72, d, 4.09, d, J = 13.9 Hz | 3.11, t, J = 4.0 Hz | 1.30-1.80, m |
8 g | (C = O)OPr (1.01, t; 1.75, m; 4.22, t) | ---- | 7.89, dd, J = 8.5 Hz J = 2.1 Hz | 7.71, d, J = 1.9 Hz | 6.86, d, J = 8.5 Hz | 3.44, d, 3.91, d, J = 6.2 Hz | 3.75, d, 4.10, d, J = 13.8 Hz | 3.15, t, J = 4.0 Hz | 1.30-1.80, m |
8 h | (C = O)OBu (0.96, m; 1.44, m; 1.71, qn; 4.26, t) | ---- | 7.88, dd, J = 8.5 Hz, J = 2.1 Hz | 7.69, d, J = 2.1 Hz | 6.83, d, J = 8.5 Hz | 3.36, d, 3.85, d, J = 6.6 Hz | 3.72, d, 4.09, d, J = 13.9 Hz | 3.10, t, J = 4.0 Hz | 1.30-1.80, m |
8i | H (6.77, td) | 10.60, bs | 7.17, dd, J = 8.0 Hz J = 1.2 Hz | 6.96, d, J = 7.2 Hz | 6.82, dd, J = 8.1 Hz, J = 1.0 Hz | 3.42, d 3.84, d, J = 6.6 Hz | 3.67, d, 4,06, d, J = 13.8 Hz | 3.11, t, J = 4.0 Hz | 1.30-1.80, m |
8j | Me (2.24, s) | 10.62, bs | 6.99, d, J = 8.2 Hz | 6.79, s | 6.74, d, J = 8.2 Hz | 3.44, d 3.83, d, J = 6.5 Hz | 3.64, d, 4.04, d, J = 13.7 Hz | 3.12, t, J = 4.1 Hz | 1.30-1.80, m |
8 k | t-Bu (1.27, s) | 10.62, bs | 7.19, dd, J = 8.5 Hz, J = 2.4 Hz | 6.96, d, J = 2.4 Hz | 6.75, d, J = 8.5 Hz | 3.47, d 3.86, d, J = 6.6 Hz | 3.67, d 4.07, d, J = 13.8 Hz | 3,11, t, J = 4.3 Hz | 1.30-1.80, m |
8 l | OMe (3.71, s) | 10.15, bs | 6.73, d, J = 8.8 Hz | 6.53, d, J = 2.0 Hz | 6.75, d, J = 8.8 Hz | 3.42, d 3.83, d, J = 6.5 Hz | 3.62, d 4.02, d, J = 13.7 Hz | 3,11, t, J = 4.1 Hz | 1.30-1.80, m |