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Table 4 Concentration of toxic metals (Pb, Hg, Cd, As) in tablets compared to maximum accepted level, and daily intake (DI) as recommended on tablet label and compared to recommended daily allowance and permitted levels

From: Evaluation of heavy metals content in dietary supplements in Lebanon

Sample ID

Pb (μg/g)

DI* (μg/day) Pb

Hg (μg/g)

DI* (μg/day) Hg

Cd (μg/g)

DI* (μg/day) Cd

As (μg/g)

DI* (μg/day) As

V1

0.125

0.43

0.014

0.048

2.333

7.889

0.514

1.700

V2

0.161

0.12

0.015

0.011

0.552

0.401

0.095

0.069

V3

0.269

0.34

0.026

0.033

2.510

3.125

0.075

0.094

VM1

0.126

0.09

0.035

0.024

2.914

2.001

0.477

0.345

VM2

0.074

0.12

0.022

0.036

2.554

4.208

0.514

0.848

VM3

0.074

0.07

0.021

0.021

0.881

0.871

1.621

1.800

VM4

0.044

0.02

0.011

0.005

2.621

1.300

0.608

0.304

VM5

0.086

0.13

0.550

0.831

0.319

0.482

0.115

0.174

VM6

0.098

0.15

0.065

0.098

2.205

3.058

0.097

0.147

VM7

0.045

0.07

0.045

0.072

2.131

3.431

0.606

0.310

VM8

0.092

0.12

0.075

0.101

2.446

3.302

0.065

0.088

VM9

0.067

0.10

0.115

0.173

2.326

3.489

0.254

0.381

VM10

0.132

0.10

0.065

0.047

2.227

1.626

1.095

0.796

VM11

0.067

0.29

0.038

0.166

1.921

8.371

0.086

0.375

VM12

0.077

0.28

0.025

0.091

1.633

5.911

0.045

0.163

VM13

0.096

0.14

0.082

0.114

0.107

0.152

0.574

0.815

M1

0.071

0.22

0.093

0.278

0.821

2.537

0.013

0.038

M2

0.029

0.04

0.055

0.072

2.516

3.271

0.034

0.045

M3

0.071

0.27

0.044

0.167

1.820

6.916

0.057

0.217

M4

0.41

1.29

0.078

0.249

0.222

0.638

0.014

0.046

M5

0.012

0.05

0.015

0.066

2.139

9.433

0.068

0.300

M6

0.13

0.25

0.025

0.049

2.534

4.850

0.035

0.068

M7

0.097

0.13

0.044

0.054

0.196

0.143

0.066

0.089

H1

0.206

0.14

0.121

0.083

2.551

1.760

0.047

0.034

H2

0.109

0.14

0.255

0.329

1.493

1.922

0.055

0.071

H3

0.039

0.02

0.095

0.049

0.143

0.074

0.466

0.242

H4

0.247

0.16

0.085

0.055

0.540

0.351

0.699

0.454

H5

0.269

0.21

0.351

0.270

2.473

1.902

0.012

0.009

H6

0.029

0.02

0.243

0.175

0.294

0.288

0.023

0.017

H7

0.005

0.01

0.027

0.020

0.834

0.609

0.032

0.023

H8

0.045

0.02

0.011

0.006

0.599

0.317

0.076

0.040

H9

0.271

0.09

0.098

0.031

0.096

0.031

0.056

0.018

H10

0.058

0.03

0.011

0.005

0.086

0.042

0.022

0.011

MAL**

0.5 a

 

1.5 a

 

2.5 a

 

0.15 a

 

PDE†

 

5 a

 

15 a

 

25 a

 

1.5 a

RDA/FDA‡

        

WHO/FAO‡‡

 

21.4 b

 

3.42 c

 

6 d

 

10 e

  1. *DI: daily intake calculated from mass of tablet and labeled recommended tablets per day.
  2. **MAL: Maximum accepted levels of metals in Tablets (μg/g)according to US Pharmacopeia (USP).
  3. †PDE: Permitted Daily exposure (μg/day) according to US Pharmacopeia (USP) for 50 kg body weight.
  4. ‡RDA: Recommended daily allowance after FDA [6].
  5. ‡‡WHO/FAO : Permissible daily intake calculated from using provisional tolerable intake and body weight of 60 kg and 10% due to dietary supplements [35].
  6. aUSP [19]b JECFA [38]c JECFA [43]d JECFA [47]e JECFA [50].
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BMC Chemistry

ISSN: 2661-801X

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