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Table 4 Concentration of toxic metals (Pb, Hg, Cd, As) in tablets compared to maximum accepted level, and daily intake (DI) as recommended on tablet label and compared to recommended daily allowance and permitted levels

From: Evaluation of heavy metals content in dietary supplements in Lebanon

Sample ID Pb (μg/g) DI* (μg/day) Pb Hg (μg/g) DI* (μg/day) Hg Cd (μg/g) DI* (μg/day) Cd As (μg/g) DI* (μg/day) As
V1 0.125 0.43 0.014 0.048 2.333 7.889 0.514 1.700
V2 0.161 0.12 0.015 0.011 0.552 0.401 0.095 0.069
V3 0.269 0.34 0.026 0.033 2.510 3.125 0.075 0.094
VM1 0.126 0.09 0.035 0.024 2.914 2.001 0.477 0.345
VM2 0.074 0.12 0.022 0.036 2.554 4.208 0.514 0.848
VM3 0.074 0.07 0.021 0.021 0.881 0.871 1.621 1.800
VM4 0.044 0.02 0.011 0.005 2.621 1.300 0.608 0.304
VM5 0.086 0.13 0.550 0.831 0.319 0.482 0.115 0.174
VM6 0.098 0.15 0.065 0.098 2.205 3.058 0.097 0.147
VM7 0.045 0.07 0.045 0.072 2.131 3.431 0.606 0.310
VM8 0.092 0.12 0.075 0.101 2.446 3.302 0.065 0.088
VM9 0.067 0.10 0.115 0.173 2.326 3.489 0.254 0.381
VM10 0.132 0.10 0.065 0.047 2.227 1.626 1.095 0.796
VM11 0.067 0.29 0.038 0.166 1.921 8.371 0.086 0.375
VM12 0.077 0.28 0.025 0.091 1.633 5.911 0.045 0.163
VM13 0.096 0.14 0.082 0.114 0.107 0.152 0.574 0.815
M1 0.071 0.22 0.093 0.278 0.821 2.537 0.013 0.038
M2 0.029 0.04 0.055 0.072 2.516 3.271 0.034 0.045
M3 0.071 0.27 0.044 0.167 1.820 6.916 0.057 0.217
M4 0.41 1.29 0.078 0.249 0.222 0.638 0.014 0.046
M5 0.012 0.05 0.015 0.066 2.139 9.433 0.068 0.300
M6 0.13 0.25 0.025 0.049 2.534 4.850 0.035 0.068
M7 0.097 0.13 0.044 0.054 0.196 0.143 0.066 0.089
H1 0.206 0.14 0.121 0.083 2.551 1.760 0.047 0.034
H2 0.109 0.14 0.255 0.329 1.493 1.922 0.055 0.071
H3 0.039 0.02 0.095 0.049 0.143 0.074 0.466 0.242
H4 0.247 0.16 0.085 0.055 0.540 0.351 0.699 0.454
H5 0.269 0.21 0.351 0.270 2.473 1.902 0.012 0.009
H6 0.029 0.02 0.243 0.175 0.294 0.288 0.023 0.017
H7 0.005 0.01 0.027 0.020 0.834 0.609 0.032 0.023
H8 0.045 0.02 0.011 0.006 0.599 0.317 0.076 0.040
H9 0.271 0.09 0.098 0.031 0.096 0.031 0.056 0.018
H10 0.058 0.03 0.011 0.005 0.086 0.042 0.022 0.011
MAL** 0.5 a   1.5 a   2.5 a   0.15 a  
PDE   5 a   15 a   25 a   1.5 a
RDA/FDA         
WHO/FAO‡‡   21.4 b   3.42 c   6 d   10 e
  1. *DI: daily intake calculated from mass of tablet and labeled recommended tablets per day.
  2. **MAL: Maximum accepted levels of metals in Tablets (μg/g)according to US Pharmacopeia (USP).
  3. PDE: Permitted Daily exposure (μg/day) according to US Pharmacopeia (USP) for 50 kg body weight.
  4. RDA: Recommended daily allowance after FDA [6].
  5. ‡‡WHO/FAO : Permissible daily intake calculated from using provisional tolerable intake and body weight of 60 kg and 10% due to dietary supplements [35].
  6. aUSP [19]b JECFA [38]c JECFA [43]d JECFA [47]e JECFA [50].