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Table 5 Robustness Study of Prednisolone

From: Stability indicating HPLC method for the simultaneous determination of moxifloxacin and prednisolone in pharmaceutical formulations

Chromatographic Conditions Assay % tR(min) Theoretical plates Tailing
Methanol:buffer (64:36) 99.2 6.947 6328 1.01
Methanol:buffer (62:38) 100.8 7.447 6277 1.01
Methanol:buffer (60:40) 99.7 8.499 6341 1.01
Flow rate (1.3 mL/min) 99.4 8.433 6358 1.01
Flow rate (1.5 mL/min) 100.5 7.447 6249 1.02
Flow rate (1.7 mL/min) 100.4 6.569 6371 1.01
Buffer (pH 2.6) 100.4 7.497 6395 1.00
Buffer (pH 2.8) 99.9 7.447 6354 1.02
Buffer (pH 3.0) 98.8 7.498 6248 1.00