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Table 4 Robustness study of moxifloxacin

From: Stability indicating HPLC method for the simultaneous determination of moxifloxacin and prednisolone in pharmaceutical formulations

Chromatographic conditions Assay % tR(min) Theoretical plates Tailing
Methanol:buffer (64:36) 99.1 3.241 4347 1.26
Methanol:buffer (62:38) 102.0 3.446 4328 1.26
Methanol:buffer (60:40) 100.5 3.615 4498 1.24
Flow rate (1.3 mL/min) 100.8 3.825 4448 1.26
Flow rate (1.5 mL/min) 98.4 3.447 4319 1.26
Flow rate (1.7 mL/min) 98.2 3.089 4358 1.26
Buffer (pH 2.6) 101.0 3.442 4348 1.24
Buffer (pH 2.8) 100.9 3.446 4442 1.26
Buffer (pH 3.0) 101.2 3.443 4488 1.24