Skip to main content

Table 2 Summary of stress degradation studies of prednisolone acetate (1).

From: Stress degradation studies and development of stability-indicating TLC-densitometry method for determination of prednisolone acetate and chloramphenicol in their individual and combined pharmaceutical formulations

Degradation conditions % Degradation Rf of degraded products
Acidic hydrolysisa   
1N HCl 76.26 0.01, 0.03,0.17, 0.19, 0.29, 0.73
5N HCl 100 0.01, 0.02, 0.03, 0.29, 0.58,0.78,0.80
Basic hydrolysisa   
0.1N NaOH 100 0.01, 0.02, 0.17, 0.36, 0.50,0.78
1N NaOH 100 0.01, 0.02, 0.03, 0.29, 0.50
5N NaOH 100 0.01, 0.02, 0.29, 0.50
Neutral hydrolysisa   
H2O 77.26 0.01, 0.02, 0.17, 0.29
Wet heatinga 95.86 0.01, 0.17, 0.26, 0.29, 0.46, 0.47, 0.80
Dry heating 18.566 0.01, 0.17, 0.26, 0.47, 0.78
Photochemical 100 0.01, 0.29, 0.33, 0.47, 0.58, 0.73
Oxidation   
35%v/v H2O2 a 21.05 0.05, 0.14, 0.29
Oxidation at room temp 5.47 0.05, 0.14, 0.29
  1. aReflux in parallel synthesizer for two hours at 80°C
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us