Table 2 Summary of stress degradation studies of prednisolone acetate (1).

Acidic hydrolysis^a

1N HCl

76.26

0.01, 0.03,0.17, 0.19, 0.29, 0.73

5N HCl

100

0.01, 0.02, 0.03, 0.29, 0.58,0.78,0.80

Basic hydrolysis^a

0.1N NaOH

100

0.01, 0.02, 0.17, 0.36, 0.50,0.78

1N NaOH

100

0.01, 0.02, 0.03, 0.29, 0.50

5N NaOH

100

0.01, 0.02, 0.29, 0.50

Neutral hydrolysis^a

H₂O

77.26

0.01, 0.02, 0.17, 0.29

Wet heating^a

95.86

0.01, 0.17, 0.26, 0.29, 0.46, 0.47, 0.80

Dry heating

18.566

0.01, 0.17, 0.26, 0.47, 0.78

Photochemical

100

0.01, 0.29, 0.33, 0.47, 0.58, 0.73

Oxidation

35%v/v H₂O₂ ^a

21.05

0.05, 0.14, 0.29

Oxidation at room temp

5.47

0.05, 0.14, 0.29