Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties

Al-Said, Mansour S; Ghorab, Mostafa M; Nissan, Yassin M

doi:10.1186/1752-153X-6-64

Table 3 In vitro anticancer screening of the synthesized compounds against human breast cell line (MCF7)

From: Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties

Comp NO.	Compound concentration (μM)				IC₅₀(μM)
	10 μM	25 μM	50 μM	100 μM
	Surviving fraction (Mean ± S.E.)^*
Doxorubicin	0.721 ± 0.02	0.546 ± 0.02	0.461 ± 0.01	0.494 ± 0.03	71.80
2	0.727 ± 0.134	0.427 ± 0.055	0.307 ± 0.029	0.317 ± 0.021	46.57
3	0.793 ± 0.055	0.454 ± 0.097	0.292 ± 0.008	0.332 ± 0.050	52.45
4	0.840 ± 0.063	0.435 ± 0.035	0.403 ± 0.015	0.335 ± 0.082	54.37
5	0.906 ± 0.021	0.642 ± 0.059	0.428 ± 0.038	0.547 ± 0.046	81.22
6	0.732 ± 0.333	0.584 ± 0.046	0.406 ± 0.069	0.229 ± 0.097	49.65
7	0.761 ± 0.190	0.546 ± 0.123	0.254 ± 0.031	0.297 ± 0.048	47.83
8	0.830 ± 0.124	0.399 ± 0.082	0.199 ± 0.021	0.272 ± 0.005	42.56
9	0.649 ± 0.028	0.394 ± 0.339	0.207 ± 0.027	0.261 ± 0.049	37.29
10	0.609 ± 0.059	0.479 ± 0.095	0.332 ± 0.058	0.316 ± 0.064	45.45
11	0.747 ± 0.197	0.359 ± 0.052	0.153 ± 0.020	0.189 ± 0.002	35.40
12	0.604 ± 0.075	0.232 ± 0.019	0.376 ± 0.089	0.312 ± 0.029	40.12
13	0.650 ± 0.184	0.401 ± 0.016	0.253 ± 0.021	0.401 ± 0.017	45.77
14	0.875 ± 0.066	0.580 ± 0.046	0.336 ± 0.049	0.467 ± 0.047	65.58
15	0.886 ± 0.047	0.423 ± 0.024	0.259 ± 0.054	0.389 ± 0.047	52.48
16	0.669 ± 0.114	0.539 ± 0.088	0.276 ± 0.064	0.259 ± 0.080	44.62
17	0.509 ± 0.235	0.230 ± 0.139	0.300 ± 0.134	0.279 ± 0.065	29.86
18	0.865 ± 0.057	0.615 ± 0.048	0.232 ± 0.046	0.286 ± 0.071	50.74
19	0.815 ± 0.042	0.545 ± 0.109	0.264 ± 0.044	0.336 ± 0.096	51.48
20	0.703 ± 0.189	0.427 ± 0.194	0.251 ± 0.026	0.374 ± 0.085	46.26
21	0.941 ± 0.020	0.472 ± 0.209	0.199 ± 0.090	0.278 ± 0.108	47.49
22	0.653 ± 0.291	0.574 ± 0.180	0.337 ± 0.116	0.359 ± 0.044	52.74
23	0.878 ± 0.032	0.563 ± 0.065	0.276 ± 0.031	0.389 ± 0.058	56.37
24	0.648 ± 0.329	0.280 ± 0.154	0.174 ± 0.105	0.194 ± 0.065	30.99

* Each value is the mean of three values ± Standard Error.

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