A reactivity-selectivity study of the Friedel-Crafts acetylation of 3,3′-dimethylbiphenyl and the oxidation of the acetyl derivatives

Table 1 Results from Friedel-Crafts acetylation of 3,3′-dimethylbiphenyl using the Perrier addition procedure ^a

Run No	Solvent	Temp (°C)	Yield (%)	Isomer distribution (%) 4-Ac
1	ClCH₂CH₂Cl	25	56.5	100
2	CS₂	25	55.1	100
3	CH₃NO₂	25	57.5	100
4	ClCH₂CH₂Cl	45	51.9	100
5	CS₂	45	60.8	100
6	CH₃NO₂	45	47.2	100

^a The 3,3′-dmbp:AcCl:AlCl₃ molar ratio was 1:1:1 and the reaction time was 3 h.

ISSN: 2661-801X