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Table 1 Relative amino acid composition of three key dermal ECM proteins. Monomeric type I collagen ([α1(I)]2α2(I), accession numbers P02452 (α1) and P08123 (α2)) is rich in Gly and Pro but contains few UV-B chromophores (Cys, His, Phe, Trp and Tyr). In contrast, fibronectin, (accession number P02751) and in particular fibrillin-1 (accession number P35555), are rich in UV-B chromophores and in the case of Fibrillin-1 Cys residues [9].

From: Chemical consequences of cutaneous photoageing

Amino Acid Collagen I (%) Fibronectin (%) Fibrillin-1 (%)
Ala (A) 11.2 4.0 3.2
Arg (R) 5.1 5.2 4.5
Asn (n) 1.5 4.2 6.6
Asp (D) 2.8 5.1 6.0
Cys (C) 0.0 2.6 12.7
Gln (Q) 2.6 5.5 3.6
Glu (E) 4.6 5.9 7.0
Gly (G) 33.1 8.2 10.7
His (H) 0.6 2.2 1.7
IIe (I) 1.0 4.7 5.2
Leu (L) 2.4 5.2 4.8
Lys (K) 3.4 3.2 3.9
Met (M) 0.6 1.1 1.8
Phe (F) 1.3 2.2 2.9
Pro (P) 21.8 7.9 6.2
Ser (S) 3.5 8.0 6.0
Thr (T) 1.7 10.8 5.8
Trp (W) 0.0 1.7 0.5
Tyr (Y) 0.3 4.2 3.3
Val (V) 2.6 8.0 3.8
Total chromophore content (%) 2.2 12.9 21.1