Entry
|
Compound
|
Yield% under microwave irradiation†
|
Yield% using traditional conditions‡
|
---|
1
|
10a
|
74
|
70
|
2
|
10b
|
80
|
72
|
3
|
10c
|
71
|
80
|
4
|
10d
|
n/a
|
72
|
5
|
10e
|
72
|
78
|
6
|
10f
|
72
|
70
|
7
|
10g
|
71
|
70
|
8
|
10h
|
79
|
75
|
- † Isolated yield after microwave dielectric heating in EtOH at 60°C for 10 min (hold time) in a sealed tube using a CEM Discover single-mode microwave synthesizer by moderation of the initial magnetron power (30 W), followed by treatment with aqueous base and purification by recrystallization. ‡ Isolated yield after reaction by traditional conductive heating at reflux in EtOH–CHCl3 for 1–4 h, basification with NH3 (aq) and purification by recrystallization (see reference 20 for details). n/a Experiment not investigated.