Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives

BMC Chemistry

Table 3 Comparison of isolated yields for microwave-assisted and conventional Hantzsch synthesis of thiazolyl coumarins 10

Entry	Compound	Yield% under microwave irradiation^†	Yield% using traditional conditions^‡
1	10a	74	70
2	10b	80	72
3	10c	71	80
4	10d	n/a	72
5	10e	72	78
6	10f	72	70
7	10g	71	70
8	10h	79	75

^† Isolated yield after microwave dielectric heating in EtOH at 60°C for 10 min (hold time) in a sealed tube using a CEM Discover single-mode microwave synthesizer by moderation of the initial magnetron power (30 W), followed by treatment with aqueous base and purification by recrystallization. ^‡ Isolated yield after reaction by traditional conductive heating at reflux in EtOH–CHCl₃ for 1–4 h, basification with NH₃ (aq) and purification by recrystallization (see reference 20 for details). n/a Experiment not investigated.

ISSN: 2661-801X